In the UK, nearly 10,000 people die each year from cancers of the oesophagus and stomach and this number is predicted to rise. The Imperial College London VOC Laboratory has developed an oesophagogastric cancer detection model based on VOCs in baseline exhaled breath (AU-ROC 0.92). This study aims to understand 'where, why and how' these compounds are produced by specifically interrogating the reprogrammed tumour lipidome, since many of the terminal VOCs identified in breath are downstream products of lipid breakdown.
Aims
Methods
Prospective, single centre, interventional study. 100 patients recruited at 1:1 ratio: (i) confirmed oesophageal/GEJ adenocarcinoma and (ii) benign conditions/normal GI tract. Breath samples collected using standardised procedure on TD tubes and analysed using mid-polar, polar and 2D GC-MS-TOF. Includes in vitro and ex vivo experiments investigating the kinetics of VOC production from lipids.
Recruitment to this trial takes place through participating NHS centres. If you think you may be eligible, please speak with your GP or hospital clinician who can refer you through the appropriate pathway.
Healthcare professional enquiries: Bhamini Vadhwana