Publications

Peer-review publications in breath analysis and its molecular drivers
  1. Belluomo I, Whitlock SE, Myridakis A, Parker AG, Converso V, Perkins MJ, Langford VS, Španěl P, Hanna GB. Combining Thermal Desorption with Selected Ion Flow Tube Mass Spectrometry for Analyses of Breath Volatile Organic Compounds. Anal Chem. 2024 Jan 30;96(4):1397-1401. doi: 10.1021/acs.analchem.3c04286. PMID: 38243802.
  2. Myridakis A, Wen Q, Boshier PR, Parker AG, Belluomo I, Handakas E, Hanna GB. Global Urinary Volatolomics with (GC×)GC-TOF-MS. Anal Chem. 2023 Nov 28;95(47):17170-17176. doi: 10.1021/acs.analchem.3c02523. PMID: 37967208.
  3. Wen Q, Myridakis A, Boshier PR, Zuffa S, Belluomo I, Parker AG, Chin ST, Hakim S, Markar SR, Hanna GB. A Complete Pipeline for Untargeted Urinary Volatolomic Profiling with Sorptive Extraction and Dual Polar and Nonpolar Column Methodologies Coupled with Gas Chromatography Time-of-Flight Mass Spectrometry. Anal Chem. 2023 Jan 17;95(2):758-765. doi: 10.1021/acs.analchem.2c02873. PMID: 36602225.
  4. Woodfield G, Belluomo I, Laponogov I, Veselkov K; COBRA1 WORKING GROUP; Cross AJ, Hanna GB. Diagnostic Performance of a Noninvasive Breath Test for Colorectal Cancer: COBRA1 Study. Gastroenterology. 2022 Nov;163(5):1447-1449.e8. doi: 10.1053/j.gastro.2022.06.084. PMID: 35803311.
  5. Belluomo I, Boshier PR, Myridakis A, Vadhwana B, Markar SR, Spanel P, Hanna GB. Selected ion flow tube mass spectrometry for targeted analysis of volatile organic compounds in human breath. Nat Protoc. 2021 Jul;16(7):3419-3438. doi: 10.1038/s41596-021-00542-0. PMID: 34089020.
  6. Antonowicz S, Bodai Z, Wiggins T, Markar SR, Boshier PR, Goh YM, Adam ME, Lu H, Kudo H, Rosini F, Goldin R, Moralli D, Green CM, Peters CJ, Habib N, Gabra H, Fitzgerald RC, Takats Z, Hanna GB. Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma. Nat Commun. 2021 Mar 5;12(1):1454. doi: 10.1038/s41467-021-21800-5. PMID: 33674602.
  7. Aksenov AA, Laponogov I, Zhang Z, Doran SLF, Belluomo I, Veselkov D, Bittremieux W, Nothias LF, Nothias-Esposito M, Maloney KN, Misra BB, Melnik AV, Smirnov A, Du X, Jones KL 2nd, Dorrestein K, Panitchpakdi M, Ernst M, van der Hooft JJJ, Gonzalez M, Carazzone C, Amézquita A, Callewaert C, Morton JT, Quinn RA, Bouslimani A, Orio AA, Petras D, Smania AM, Couvillion SP, Burnet MC, Nicora CD, Zink E, Metz TO, Artaev V, Humston-Fulmer E, Gregor R, Meijler MM, Mizrahi I, Eyal S, Anderson B, Dutton R, Lugan R, Boulch PL, Guitton Y, Prevost S, Poirier A, Dervilly G, Le Bizec B, Fait A, Persi NS, Song C, Gashu K, Coras R, Guma M, Manasson J, Scher JU, Barupal DK, Alseekh S, Fernie AR, Mirnezami R, Vasiliou V, Schmid R, Borisov RS, Kulikova LN, Knight R, Wang M, Hanna GB, Dorrestein PC, Veselkov K. Auto-deconvolution and molecular networking of gas chromatography-mass spectrometry data. Nat Biotechnol. 2021 Feb;39(2):169-173. doi: 10.1038/s41587-020-0700-3. PMID: 33169034.
  8. Kamal F, Kumar S, Edwards MR, Veselkov K, Belluomo I, Kebadze T, Romano A, Trujillo-Torralbo MB, Shahridan Faiez T, Walton R, Ritchie AI, Wiseman DJ, Laponogov I, Donaldson G, Wedzicha JA, Johnston SL, Singanayagam A, Hanna GB. Virus-induced Volatile Organic Compounds Are Detectable in Exhaled Breath during Pulmonary Infection. Am J Respir Crit Care Med. 2021 Nov 1;204(9):1075-1085. doi: 10.1164/rccm.202103-0660OC. PMID: 34319857.
  9. Lin GP, Vadhwana B, Belluomo I, Boshier PR, Španěl P, Hanna GB. Cross Platform Analysis of Volatile Organic Compounds Using Selected Ion Flow Tube and Proton-Transfer-Reaction Mass Spectrometry. J Am Soc Mass Spectrom. 2021 May 5;32(5):1215-1223. doi: 10.1021/jasms.1c00027. PMID: 33831301.
  10. Woodfield G, Belluomo I, Boshier PR, Waller A, Fayyad M, von Wagner C, Cross AJ, Hanna GB. Feasibility and acceptability of breath research in primary care: a prospective, cross-sectional, observational study. BMJ Open. 2021 Apr 13;11(4):e044691. doi: 10.1136/bmjopen-2020-044691. PMID: 33849851.
  11. Hanna GB, Cross AJ. Editorial: volatile organic compound analysis to improve faecal immunochemical testing in the detection of colorectal cancer. Aliment Pharmacol Ther. 2021 Aug;54(4):504-505. doi: 10.1111/apt.16471. PMID: 34331792.
  12. Wen Q, Boshier P, Myridakis A, Belluomo I, Hanna GB. Urinary Volatile Organic Compound Analysis for the Diagnosis of Cancer: A Systematic Literature Review and Quality Assessment. Metabolites. 2020 Dec 29;11(1):17. doi: 10.3390/metabo11010017. PMID: 33383923.
  13. Goh YM, Antonowicz SS, Boshier P, Hanna GB. Metabolic Biomarkers of Squamous Cell Carcinoma of the Aerodigestive Tract: A Systematic Review and Quality Assessment. Oxid Med Cell Longev. 2020 Feb 21;2020:2930347. doi: 10.1155/2020/2930347. PMID: 32685090.
  14. Abbassi-Ghadi N, Antonowicz SS, McKenzie JS, Kumar S, Huang J, Jones EA, Strittmatter N, Petts G, Kudo H, Court S, Hoare JM, Veselkov K, Goldin R, Takáts Z, Hanna GB. De Novo Lipogenesis Alters the Phospholipidome of Esophageal Adenocarcinoma. Cancer Res. 2020 Jul 1;80(13):2764-2774. doi: 10.1158/0008-5472.CAN-19-4035. Epub 2020 Apr 28. PMID: 32345674.
  15. Vadhwana B, Belluomo I, Boshier PR, Pavlou C, Španěl P, Hanna GB. Impact of oral cleansing strategies on exhaled volatile organic compound levels. Rapid Commun Mass Spectrom. 2020 May 15;34(9):e8706. doi: 10.1002/rcm.8706. PMID: 31880852.
  16. Markar SR, Chin ST, Romano A, Wiggins T, Antonowicz S, Paraskeva P, Ziprin P, Darzi A, Hanna GB. Breath Volatile Organic Compound Profiling of Colorectal Cancer Using Selected Ion Flow-tube Mass Spectrometry. Ann Surg. 2019 May;269(5):903-910. doi: 10.1097/SLA.0000000000002539. PMID: 29194085.
  17. Hanna GB, Boshier PR, Markar SR, Romano A. Accuracy and Methodologic Challenges of Volatile Organic Compound-Based Exhaled Breath Tests for Cancer Diagnosis: A Systematic Review and Meta-analysis. JAMA Oncol. 2019 Jan 1;5(1):e182815. doi: 10.1001/jamaoncol.2018.2815. Epub 2019 Jan 10. Erratum in: JAMA Oncol. 2019 Jul 1;5(7):1070. PMID: 30128487.
  18. Adam ME, Fehervari M, Boshier PR, Chin ST, Lin GP, Romano A, Kumar S, Hanna GB. Mass-Spectrometry Analysis of Mixed-Breath, Isolated-Bronchial-Breath, and Gastric-Endoluminal-Air Volatile Fatty Acids in Esophagogastric Cancer. Anal Chem. 2019 Mar 5;91(5):3740-3746. doi: 10.1021/acs.analchem.9b00148. PMID: 30699297.
  19. Romano A, Hanna GB. Identification and quantification of VOCs by proton transfer reaction time of flight mass spectrometry: An experimental workflow for the optimization of specificity, sensitivity, and accuracy. J Mass Spectrom. 2018 Apr;53(4):287-295. doi: 10.1002/jms.4063. PMID: 29336521.
  20. Romano A, Doran S, Belluomo I, Hanna GB. High-Throughput Breath Volatile Organic Compound Analysis Using Thermal Desorption Proton Transfer Reaction Time-of-Flight Mass Spectrometry. Anal Chem. 2018 Sep 4;90(17):10204-10210. doi: 10.1021/acs.analchem.8b01045. PMID: 30106567.
  21. Markar SR, Wiggins T, Antonowicz S, Chin ST, Romano A, Nikolic K, Evans B, Cunningham D, Mughal M, Lagergren J, Hanna GB. Assessment of a Noninvasive Exhaled Breath Test for the Diagnosis of Oesophagogastric Cancer. JAMA Oncol. 2018 Jul 1;4(7):970-976. doi: 10.1001/jamaoncol.2018.0991. PMID: 29799976.
  22. Markar SR, Brodie B, Chin ST, Romano A, Spalding D, Hanna GB. Profile of exhaled-breath volatile organic compounds to diagnose pancreatic cancer. Br J Surg. 2018 Oct;105(11):1493-1500. doi: 10.1002/bjs.10909. PMID: 30019405.
  23. Boshier PR, Fehervari M, Markar SR, Purkayastha S, Spanel P, Smith D, Hanna GB. Variation in Exhaled Acetone and Other Ketones in Patients Undergoing Bariatric Surgery: a Prospective Cross-sectional Study. Obes Surg. 2018 Aug;28(8):2439-2446. doi: 10.1007/s11695-018-3180-5. PMID: 29516396.
  24. Antonowicz S, Hanna GB, Takats Z, Bodai Z. Pragmatic and rapid analysis of carbonyl, oxidation and chlorination nucleoside-adducts in murine tissue by UPLC-ESI-MS/MS. Talanta. 2018 Dec 1;190:436-442. doi: 10.1016/j.talanta.2018.08.029. PMID: 30172530.
  25. Doran SLF, Romano A, Hanna GB. Optimisation of sampling parameters for standardised exhaled breath sampling. J Breath Res. 2017 Dec 6;12(1):016007. doi: 10.1088/1752-7163/aa8a46. PMID: 29211685.
  26. Boshier PR, Knaggs AL, Hanna GB, Marczin N. Perioperative changes in exhaled nitric oxide during oesophagectomy. J Breath Res. 2017 Nov 7;11(4):047109. doi: 10.1088/1752-7163/aa9387. PMID: 29033395.
  27. Pabary R, Huang J, Kumar S, Alton EW, Bush A, Hanna GB, Davies JC. Does mass spectrometric breath analysis detect Pseudomonas aeruginosa in cystic fibrosis? Eur Respir J. 2016 Mar;47(3):994-7. doi: 10.1183/13993003.00944-2015. PMID: 26846826.
  28. Huddy JR, Weldon SM, Ralhan S, Painter T, Hanna GB, Kneebone R, Bello F. Sequential simulation (SqS) of clinical pathways: a tool for public and patient engagement in point-of-care diagnostics. BMJ Open. 2016 Sep 13;6(9):e011043. doi: 10.1136/bmjopen-2016-011043. PMID: 27625053.
  29. Antonowicz S, Kumar S, Wiggins T, Markar SR, Hanna GB. Diagnostic Metabolomic Blood Tests for Endoluminal Gastrointestinal Cancer–A Systematic Review and Assessment of Quality. Cancer Epidemiol Biomarkers Prev. 2016 Jan;25(1):6-15. doi: 10.1158/1055-9965.EPI-15-0524. PMID: 26598534.
  30. Abbassi-Ghadi N, Jones EA, Gomez-Romero M, Golf O, Kumar S, Huang J, Kudo H, Goldin RD, Hanna GB, Takats Z. A Comparison of DESI-MS and LC-MS for the Lipidomic Profiling of Human Cancer Tissue. J Am Soc Mass Spectrom. 2016 Feb;27(2):255-64. doi: 10.1007/s13361-015-1278-8. PMID: 26466600.
  31. Abbassi-Ghadi N, Golf O, Kumar S, Antonowicz S, McKenzie JS, Huang J, Strittmatter N, Kudo H, Jones EA, Veselkov K, Goldin R, Takats Z, Hanna GB. Imaging of Esophageal Lymph Node Metastases by Desorption Electrospray Ionization Mass Spectrometry. Cancer Res. 2016 Oct 1;76(19):5647-5656. doi: 10.1158/0008-5472.CAN-16-0699. PMID: 27364550.
  32. Wiggins T, Kumar S, Markar SR, Antonowicz S, Hanna GB. Tyrosine, phenylalanine, and tryptophan in gastroesophageal malignancy: a systematic review. Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):32-8. doi: 10.1158/1055-9965.EPI-14-0980. PMID: 25344892.
  33. Markar SR, Wiggins T, Kumar S, Hanna GB. Exhaled breath analysis for the diagnosis and assessment of endoluminal gastrointestinal diseases. J Clin Gastroenterol. 2015 Jan;49(1):1-8. doi: 10.1097/MCG.0000000000000247. PMID: 25319742.
  34. Kumar S, Huang J, Abbassi-Ghadi N, Mackenzie HA, Veselkov KA, Hoare JM, Lovat LB, Španěl P, Smith D, Hanna GB. Mass Spectrometric Analysis of Exhaled Breath for the Identification of Volatile Organic Compound Biomarkers in Esophageal and Gastric Adenocarcinoma. Ann Surg. 2015 Dec;262(6):981-90. doi: 10.1097/SLA.0000000000001101. PMID: 25575255.
  35. Hicks LC, Huang J, Kumar S, Powles ST, Orchard TR, Hanna GB, Williams HR. Analysis of Exhaled Breath Volatile Organic Compounds in Inflammatory Bowel Disease: A Pilot Study. J Crohns Colitis. 2015 Sep;9(9):731-7. doi: 10.1093/ecco-jcc/jjv102. PMID: 26071410.
  36. Chadwick G, Groene O, Riley S, Hardwick R, Crosby T, Hoare J, Hanna GB, Greenaway K, Cromwell DA. Gastric Cancers Missed During Endoscopy in England. Clin Gastroenterol Hepatol. 2015 Jul;13(7):1264-1270.e1. doi: 10.1016/j.cgh.2015.01.025. PMID: 25645877.
  37. Boshier PR, Mistry V, Cushnir JR, Kon OM, Elkin SL, Curtis S, Marczin N, Hanna GB. Breath metabolite response to major upper gastrointestinal surgery. J Surg Res. 2015 Feb;193(2):704-12. doi: 10.1016/j.jss.2014.09.004. PMID: 25282400.
  38. Huang J, Kumar S, Hanna GB. Investigation of C3-C10 aldehydes in the exhaled breath of healthy subjects using selected ion flow tube-mass spectrometry (SIFT-MS). J Breath Res. 2014 Sep;8(3):037104. doi: 10.1088/1752-7155/8/3/037104. PMID: 25190002.
  39. Chadwick G, Groene O, Hoare J, Hardwick RH, Riley S, Crosby TD, Hanna GB, Cromwell DA. A population-based, retrospective, cohort study of esophageal cancer missed at endoscopy. Endoscopy. 2014 Jul;46(7):553-60. doi: 10.1055/s-0034-1365646. Epub 2014 Jun 27. PMID: 24971624.
  40. Abbassi-Ghadi N, Veselkov K, Kumar S, Huang J, Jones E, Strittmatter N, Kudo H, Goldin R, Takáts Z, Hanna GB. Discrimination of lymph node metastases using desorption electrospray ionisation-mass spectrometry imaging. Chem Commun (Camb). 2014 Apr 11;50(28):3661-4. doi: 10.1039/c3cc48927b. PMID: 24407514.
  41. Kumar S, Huang J, Abbassi-Ghadi N, Španěl P, Smith D, Hanna GB. Selected ion flow tube mass spectrometry analysis of exhaled breath for volatile organic compound profiling of esophago-gastric cancer. Anal Chem. 2013 Jun 18;85(12):6121-8. doi: 10.1021/ac4010309. PMID: 23659180.
  42. Huang J, Kumar S, Abbassi-Ghadi N, Spaněl P, Smith D, Hanna GB. Selected ion flow tube mass spectrometry analysis of volatile metabolites in urine headspace for the profiling of gastro-esophageal cancer. Anal Chem. 2013 Mar 19;85(6):3409-16. doi: 10.1021/ac4000656. PMID: 23421902.
  43. Boshier PR, Hanna GB, Marczin N. Exhaled nitric oxide as biomarker of acute lung injury: an unfulfilled promise? J Breath Res. 2013 Mar;7(1):017118. doi: 10.1088/1752-7155/7/1/017118. PMID: 23445570.
  44. Abbassi-Ghadi N, Kumar S, Huang J, Goldin R, Takats Z, Hanna GB. Metabolomic profiling of oesophago-gastric cancer: a systematic review. Eur J Cancer. 2013 Nov;49(17):3625-37. doi: 10.1016/j.ejca.2013.07.004. PMID: 23896378.
  45. Kumar S, Huang J, Cushnir JR, Španěl P, Smith D, Hanna GB. Selected ion flow tube-MS analysis of headspace vapor from gastric content for the diagnosis of gastro-esophageal cancer. Anal Chem. 2012 Nov 6;84(21):9550-7. doi: 10.1021/ac302409a. PMID: 23035898.
  46. Boshier PR, Priest OH, Hanna GB, Marczin N. Influence of respiratory variables on the on-line detection of exhaled trace gases by PTR-MS. Thorax. 2011 Oct;66(10):919-20. doi: 10.1136/thx.2011.161208. PMID: 21474496.
  47. Boshier PR, Cushnir JR, Mistry V, Knaggs A, Španěl P, Smith D, Hanna GB. On-line, real time monitoring of exhaled trace gases by SIFT-MS in the perioperative setting: a feasibility study. Analyst. 2011 Aug 21;136(16):3233-7. doi: 10.1039/c1an15356k. PMID: 21717028.
  48. Yakoub D, Keun HC, Goldin R, Hanna GB. Metabolic profiling detects field effects in nondysplastic tissue from esophageal cancer patients. Cancer Res. 2010 Nov 15;70(22):9129-36. doi: 10.1158/0008-5472.CAN-10-1566. PMID: 20884633.
  49. Boshier PR, Marczin N, Hanna GB. Repeatability of the measurement of exhaled volatile metabolites using selected ion flow tube mass spectrometry. J Am Soc Mass Spectrom. 2010 Jun;21(6):1070-4. doi: 10.1016/j.jasms.2010.02.008. PMID: 20335048.
  50. Boshier PR, Cushnir JR, Priest OH, Marczin N, Hanna GB. Variation in the levels of volatile trace gases within three hospital environments: implications for clinical breath testing. J Breath Res. 2010 Sep;4(3):031001. doi: 10.1088/1752-7155/4/3/031001. PMID: 21383476.