The breath test is intended for use as a triage tool in primary care, but most research has been conducted in secondary care settings. The MAGIC study demonstrated feasibility in primary care (1,002 patients, 99% found it easy or very easy). However, whether an individual's exhaled breath VOC profile changes when measured across primary and secondary care sites has not been investigated. HOPE addresses this gap to support clinical translation of breath research from secondary care studies to primary care implementation.
Aims
Methods
Single-centre observational study at Imperial College Healthcare Trust with 80 participants. Participants perform breath testing in primary care followed by secondary care on Day 1 (three samples, 15 minutes apart), then reversed order on Day 2. Environmental air sampled for quality control. Linear mixed models fitted for each compound to estimate components of variation and confirm no ordering effect.
Recruitment to this trial takes place through participating NHS centres. If you think you may be eligible, please speak with your GP or hospital clinician who can refer you through the appropriate pathway.
Healthcare professional enquiries: Mohamed Abulazayem · hope@imperial.ac.uk