Upper digestive tract cancers encompass all cancers from the oral cavity to the duodenum. Patients present with indeterminate symptoms, so definitive presentation tends to occur late, with a five-year survival rate of 8.3–19%. With increasing incidence worldwide, there is a need for a non-invasive diagnostic tool for earlier identification. Analysis of VOCs from breath, saliva and urine can provide a non-invasive risk-stratification tool to identify high-risk patients who would benefit from earlier endoscopy referral.
Aims
Methods
Multicentre case-control study with 300 participants divided equally between HNSCC, OAC/OSCC, and non-cancer controls. Breath samples collected using standardised procedures on TD tubes and analysed using mid-polar, polar, and 2D GC-MS-TOF. Collection of non-breath bio-samples (saliva, urine, blood, tissue) has completed recruitment.
Recruitment to this trial takes place through participating NHS centres. If you think you may be eligible, please speak with your GP or hospital clinician who can refer you through the appropriate pathway.
Healthcare professional enquiries: Sameera Sharma · ssharma@ic.ac.uk